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Mechanisms involved in the regulation of histone lysine demethylases Lan F; Nottke AC; Shi YCurr Opin Cell Biol 2008[Jun]; 20 (3): 316-25Since the first histone lysine demethylase KDM1 (LSD1) was discovered in 2004, a great number of histone demethylases have been recognized and shown to play important roles in gene expression, as well as cellular differentiation and animal development. The chemical mechanisms and substrate specificities have already been extensively discussed elsewhere. This review focuses primarily on regulatory mechanisms that modulate demethylase recruitment and activity.|Animals[MESH]|DNA-Binding Proteins/genetics/metabolism[MESH]|Epigenesis, Genetic/*genetics[MESH]|Gene Expression Regulation/genetics[MESH]|Histone Demethylases[MESH]|Histones/genetics/*metabolism[MESH]|Humans[MESH]|Methylation[MESH]|Oxidoreductases, N-Demethylating/*metabolism[MESH]|Protein Processing, Post-Translational/*genetics[MESH]|Transcription Factors/genetics/metabolism[MESH] |
