Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
IAPs: what s in a name?Srinivasula SM; Ashwell JDMol Cell 2008[Apr]; 30 (2): 123-35Originally described in insect viruses, cellular proteins with Baculoviral IAP repeat (BIR) motifs have been thought to function primarily as inhibitors of apoptosis. The subsequent finding that a subset of IAPs that contain a RING domain have ubiquitin protein ligase (E3) activity implied the presence of other functions. It is now known that IAPs are involved in mitotic chromosome segregation, cellular morphogenesis, copper homeostasis, and intracellular signaling. Here, we review the current understanding of the roles of IAPs in apoptotic and nonapoptotic processes and explore the notion that the latter represents the primary physiologic activities of IAPs.|*Apoptosis[MESH]|Amino Acid Motifs[MESH]|Animals[MESH]|Cell Movement[MESH]|Copper/metabolism[MESH]|Humans[MESH]|Immunity, Innate[MESH]|Inhibitor of Apoptosis Proteins/*chemistry/genetics/*metabolism[MESH]|Mice[MESH]|Morphogenesis[MESH]|Neoplasms/metabolism[MESH]|Signal Transduction[MESH] |
