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lüll Pharmacological topics of bone metabolism: antiresorptive microbial compounds that inhibit osteoclast differentiation, function, and survival Woo JT; Yonezawa T; Cha BY; Teruya T; Nagai KJ Pharmacol Sci 2008[Apr]; 106 (4): 547-54The mass and function of bones depends on the maintenance of a complicated balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Osteoporosis typically reflects an imbalance in skeletal turnover, such that bone resorption exceeds bone formation. Osteoclasts are target cells for anti-osteoporosis therapies. To discover new types of antiresorptive agents, we screened for natural compounds that regulate osteoclast differentiation, function, and survival. As a result, we identified reveromycin A, destruxins, mevastatin, FK506, cyclosporin A, prodigiosins, concanamycins, and symbioimine among microbial natural compounds. In this review, we discuss the mechanisms of action of these compounds on osteoclasts.|Animals[MESH]|Apoptosis/drug effects[MESH]|Bacteria/*chemistry[MESH]|Bone Density Conservation Agents/isolation & purification/*pharmacology/therapeutic use[MESH]|Bone Resorption/metabolism/pathology/*prevention & control[MESH]|Cell Differentiation/*drug effects[MESH]|Cell Survival/drug effects[MESH]|Cyclosporine/pharmacology[MESH]|Depsipeptides/pharmacology[MESH]|Fungi/*chemistry[MESH]|Heterocyclic Compounds, 3-Ring/pharmacology[MESH]|Humans[MESH]|Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology[MESH]|Lovastatin/analogs & derivatives/pharmacology[MESH]|Osteoclasts/*drug effects/metabolism/pathology[MESH]|Prodigiosin/pharmacology[MESH]|Pyrans/pharmacology[MESH]|Spiro Compounds/pharmacology[MESH]|Tacrolimus/pharmacology[MESH] |