Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Essential thrombocythemia, polycythemia vera, and myelofibrosis: current management and the prospect of targeted therapy Tefferi AAm J Hematol 2008[Jun]; 83 (6): 491-7The recent discovery of JAK2 and/or MPL mutations in polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) has had a major impact on how we diagnose and treat these disorders. For instance, the presence of a JAK2 mutation is now considered conditio sine qua non for the diagnosis of PV and the World Health Organization classification system has recently revised its diagnostic criteria for PV, ET, and PMF to include JAK2 and MPL mutations as clonal markers. From the standpoint of treatment, JAK-STAT is now identified as a legitimate target pathway for drug development in myeloproliferative neoplasms. Herein, I will first outline my views regarding current management in ET, PV, and PMF and then discuss emerging data on preclinical and clinical activity of anti-JAK2 small molecule drugs. Am. J. Hematol., 2008. (c) 2008 Wiley-Liss, Inc.|Disease Management[MESH]|Drug Delivery Systems[MESH]|Humans[MESH]|Janus Kinase 2/genetics[MESH]|Myeloproliferative Disorders/*classification/diagnosis/*drug therapy[MESH]|Polycythemia Vera/classification/diagnosis/drug therapy[MESH]|Primary Myelofibrosis/classification/diagnosis/drug therapy[MESH]|Receptors, Thrombopoietin/genetics[MESH]|Thrombocythemia, Essential/classification/diagnosis/drug therapy[MESH] |
