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Safety and efficacy of beta agonists Donohue JFRespir Care 2008[May]; 53 (5): 618-22; discussion 623-4Both short-acting and long-acting beta agonists have been used for many years for the treatment of asthma. Short-acting beta agonists are life-saving and their role as rescue agents is unquestioned, but regular use is not recommended because of safety concerns and the effectiveness of asthma-controller medications. Long-acting beta agonists are effective controller medications but have safety issues, so their use should be restricted to patients who are not optimally controlled on first-line controllers such as inhaled corticosteroids. The effect of the beta receptor genotype on beta agonist response is unclear but could hold promise for proper patient management.|Administration, Inhalation[MESH]|Adrenergic beta-Agonists/pharmacology/*therapeutic use[MESH]|Adrenergic beta-Antagonists[MESH]|Asthma/*drug therapy/genetics[MESH]|Bronchi/drug effects[MESH]|Genetic Variation[MESH]|Glucocorticoids/administration & dosage[MESH]|Humans[MESH]|Polymorphism, Genetic[MESH] |
