Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Up on the tightrope: natural killer cell activation and inhibition Lanier LLNat Immunol 2008[May]; 9 (5): 495-502Natural killer (NK) cells circulate through the blood, lymphatics and tissues, on patrol for the presence of transformed or pathogen-infected cells. As almost all NK cell receptors bind to host-encoded ligands, signals are constantly being transmitted into NK cells, whether they interact with normal or abnormal cells. The sophisticated repertoire of activating and inhibitory receptors that has evolved to regulate NK cell activity ensures that NK cells protect hosts against pathogens, yet prevents deleterious NK cell-driven autoimmune responses. Here I highlight recent advances in our understanding of the structural properties and signaling pathways of the inhibitory and activating NK cell receptors, with a particular focus on the ITAM-dependent activating receptors, the NKG2D-DAP10 receptor complexes and the CD244 receptor system.|Amino Acid Motifs/immunology[MESH]|Animals[MESH]|Antigens, CD/immunology[MESH]|Humans[MESH]|Killer Cells, Natural/*immunology[MESH]|Lymphocyte Activation[MESH]|Membrane Proteins/immunology/metabolism[MESH]|NK Cell Lectin-Like Receptor Subfamily K[MESH]|Receptors, Immunologic/antagonists & inhibitors/chemistry/immunology/metabolism[MESH]|Receptors, Natural Killer Cell[MESH]|Signal Transduction/immunology[MESH]|Tyrosine[MESH] |
