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lüll Decoding ARE-mediated decay: is microRNA part of the equation?von Roretz C; Gallouzi IEJ Cell Biol 2008[Apr]; 181 (2): 189-94Messenger ribonucleic acids (mRNAs) containing adenine/uridine-rich elements (AREs) in their 3' untranslated region are particularly labile, allowing for the regulation of expression for growth factors, oncoproteins, and cytokines. The regulators, effectors, and location of ARE-mediated decay (AMD) have been investigated by many groups in recent years, and several links have been found between AMD and microRNA-mediated decay. We highlight these similarities, along with recent advances in the field of AMD, and also mention how there is still much left unknown surrounding this specialized mode of mRNA decay.|3' Untranslated Regions/genetics[MESH]|Adenine/analysis[MESH]|Animals[MESH]|Gene Expression Regulation[MESH]|Humans[MESH]|Kinetics[MESH]|MicroRNAs/*genetics/metabolism[MESH]|Models, Genetic[MESH]|Protein Biosynthesis[MESH]|RNA, Messenger/genetics/metabolism[MESH]|Transcription, Genetic[MESH]|Uridine/analysis[MESH] |