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T-helper 17 cells in psoriatic plaques and additional genetic links between IL-23 and psoriasis Blauvelt AJ Invest Dermatol 2008[May]; 128 (5): 1064-7T-helper 17 (Th17) cells are a newly appreciated T-cell subset, distinct from both Th1 and Th2 cells, that have been implicated in the pathogenesis of psoriasis and other autoimmune inflammatory diseases (Figure 1) (Fitch et al., 2007; Kastelein et al., 2007). IL-23 stimulates survival and proliferation of Th17 cells and thus serves as a key master cytokine regulator for these diseases.|Humans[MESH]|Interleukin-23/*genetics/*immunology[MESH]|Psoriasis/*genetics/*immunology[MESH]|T-Lymphocytes, Helper-Inducer/classification/*physiology[MESH] |
