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lüll Mast cell transcriptional networks Takemoto CM; Lee YN; Jegga AG; Zablocki D; Brandal S; Shahlaee A; Huang S; Ye Y; Gowrisankar S; Huynh J; McDevitt MABlood Cells Mol Dis 2008[Jul]; 41 (1): 82-90Unregulated activation of mast cells can contribute to the pathogenesis of inflammatory and allergic diseases, including asthma, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. Absence of mast cells in animal models can lead to impairment in the innate immune response to parasites and bacterial infections. Aberrant clonal accumulation and proliferation of mast cells can result in a variety of diseases ranging from benign cutaneous mastocytosis to systemic mastocytosis or mast cell leukemia. Understanding mast cell differentiation provides important insights into mechanisms of lineage selection during hematopoiesis and can provide targets for new drug development to treat mast cell disorders. In this review, we discuss controversies related to development, sites of origin, and the transcriptional program of mast cells.|*Gene Regulatory Networks[MESH]|Animals[MESH]|GATA1 Transcription Factor/genetics/metabolism[MESH]|Humans[MESH]|Mast Cells/cytology/immunology/*physiology[MESH]|Protein Isoforms/immunology/metabolism[MESH]|Transcription Factors/*metabolism[MESH] |