suck pdf from google scholar
unlimited free pdf from europmc18394690    free
PDF from PMC    free
html from PMC    free
PDF vom PMID18394690  :  Publisher
PDF vom PMID18394690
suck pdf from library genesis
English Wikipedia

Nephropedia Template TP (

Twit Text

  • DeepDyve
  • Pubget Overpricing

  • lüll
  • Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems
  • Gore AC
  • Front Neuroendocrinol 2008[Jun]; 29 (3): 358-74
  • The ability of a species to reproduce successfully requires the careful orchestration of developmental processes during critical time points, particularly the late embryonic and early postnatal periods. This article begins with a brief presentation of the evidence for how gonadal steroid hormones exert these imprinting effects upon the morphology of sexually differentiated hypothalamic brain regions, the mechanisms underlying these effects, and their implications in adulthood. Then, I review the evidence that aberrant exposure to hormonally-active substances such as exogenous endocrine-disrupting chemicals (EDCs), may result in improper hypothalamic programming, thereby decreasing reproductive success in adulthood. The field of endocrine disruption has shed new light on the discipline of basic reproductive neuroendocrinology through studies on how early life exposures to EDCs may alter gene expression via non-genomic, epigenetic mechanisms, including DNA methylation and histone acetylation. Importantly, these effects may be transmitted to future generations if the germline is affected via transgenerational, epigenetic actions. By understanding the mechanisms by which natural hormones and xenobiotics affect reproductive neuroendocrine systems, we will gain a better understanding of normal developmental processes, as well as develop the potential ability to intervene when development is disrupted.
  • |*Behavior, Animal/drug effects/physiology[MESH]
  • |Animals[MESH]
  • |Apoptosis[MESH]
  • |Endocrine Disruptors/*pharmacology[MESH]
  • |Hypothalamus/cytology/drug effects/metabolism[MESH]
  • |Nerve Growth Factors/metabolism[MESH]
  • |Neurosecretory Systems/anatomy & histology/*drug effects/physiology[MESH]
  • |Neurotransmitter Agents/metabolism[MESH]
  • |Reproduction/*drug effects/physiology[MESH]
  • |Sex Characteristics[MESH]
  • |Steroids/metabolism[MESH]

  • *{{pmid18394690}}
    *<b>[ Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems ]</b> Front Neuroendocrinol 2008; 29(3) ; 358-74 Gore AC


    Nephropedia PMID record

    Deutsche Wikipedia - im Artikel

    Hier den unten stehenden Textblock hineinkopieren

    Front Neuroendocrinol

    358 3.29 2008