Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll IL-17 and therapeutic kynurenines in pathogenic inflammation to fungi Romani L; Zelante T; De Luca A; Fallarino F; Puccetti PJ Immunol 2008[Apr]; 180 (8): 5157-62Largely viewed as proinflammatory, innate responses combine with adaptive immunity to generate the most effective form of antifungal resistance, and T cells exercise feedback control over diverse effects of inflammation on infection. Some degree of inflammation is required for protection, particularly in mucosal tissues, during the transitional response occurring between the rapid innate and slower adaptive response. However, progressive inflammation worsens disease and ultimately prevents pathogen eradication. IDO, tryptophan catabolites ("kynurenines"), and regulatory T cells help to tame overzealous and exaggerated inflammatory responses. In this context, IL-23 and the Th17 pathway, which down-regulate tryptophan catabolism, may instead favor pathology and serve to accommodate the seemingly paradoxical association of chronic inflammation with fungal persistence. Recent data support a view in which IL-23/IL-17 antagonistic strategies, including the administration of synthetic kynurenines, could represent a new means of harnessing progressive or potentially harmful inflammation.|Animals[MESH]|Cytokines/immunology/metabolism[MESH]|Fungi/*immunology/pathogenicity[MESH]|Humans[MESH]|Immune Reconstitution Inflammatory Syndrome/immunology/metabolism[MESH]|Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism[MESH]|Inflammation/*immunology/metabolism[MESH]|Interleukin-17/immunology/*metabolism[MESH]|Interleukin-23/immunology/metabolism[MESH]|Kynurenine/immunology/*metabolism[MESH]|Mycoses/*immunology[MESH]|T-Lymphocytes, Regulatory/immunology/*metabolism[MESH]|Tryptophan/immunology/metabolism[MESH] |