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lüll Recent developments in the immunobiology of rheumatoid arthritis Andersson AK; Li C; Brennan FMArthritis Res Ther 2008[]; 10 (2): 204Progress into the understanding of immunopathology in rheumatoid arthritis is reviewed in the present article with regard to pro-inflammatory cytokine production, cell activation and recruitment, and osteoclastogenesis. Studies highlight the potential importance of T helper 17 cells and regulatory T cells in driving and suppressing inflammation in rheumatoid arthritis, respectively, and highlight other potential T-cell therapeutic targets. The genetic associations of the HLA shared epitope alleles with antibodies to citrullinated peptides in rheumatoid arthritis patients indicate that T cells are providing help to B cells to produce autoantibodies, and there is increasing evidence that these autoantibodies are pathogenic in rheumatoid arthritis.|Animals[MESH]|Arthritis, Rheumatoid/genetics/*immunology/pathology[MESH]|Autoantibodies/immunology[MESH]|Autoantigens/immunology[MESH]|B-Lymphocytes/immunology[MESH]|Genetic Predisposition to Disease[MESH]|Humans[MESH]|Lymphocyte Activation/immunology[MESH]|T-Lymphocytes/*immunology[MESH] |