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lüll Why myc? An unexpected ingredient in the stem cell cocktail Knoepfler PSCell Stem Cell 2008[Jan]; 2 (1): 18-21Screening cocktails of candidate genes for induction of pluripotency and self-renewal in nonstem cells has identified a surprising new embryonic stem cell regulator, the myc proto-oncogene. Here the possible mechanisms by which myc controls self-renewal and pluripotency are discussed.|*Cell Differentiation[MESH]|*Gene Expression Regulation, Developmental[MESH]|Animals[MESH]|Cell Cycle Proteins/genetics/metabolism[MESH]|Cell Lineage[MESH]|Embryo, Mammalian/metabolism[MESH]|Humans[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Models, Animal[MESH]|Octamer Transcription Factor-3/metabolism[MESH]|Oligonucleotide Array Sequence Analysis[MESH]|Pluripotent Stem Cells/physiology[MESH]|Proto-Oncogene Mas[MESH]|Proto-Oncogene Proteins c-myc/*physiology[MESH]|Regenerative Medicine[MESH]|SOXB1 Transcription Factors/metabolism[MESH]|STAT3 Transcription Factor/metabolism[MESH]|Signal Transduction[MESH]|Stem Cells/*physiology[MESH] |