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Complement component c1q and anti-c1q antibodies in theory and in clinical practice Potlukova E; Kralikova PScand J Immunol 2008[May]; 67 (5): 423-30The complement system is a major part of the innate immunity. The first component of the classical pathway of complement activation, C1q, plays a crucial role in the clearance of immune complexes and apoptotic bodies from the organism. Autoantibodies against C1q (anti-C1q) have been found in a number of autoimmune and infectious diseases. They have been best described in patients with systemic lupus erythematosus, where they are thought to play a pathogenic role in lupus nephritis (LN). Their high negative predictive value for the occurrence of active proliferative LN, as well as their possible ability to indicate a renal flare as soon as 6 months in advance, have rendered anti-C1q antibodies a novel non-invasive tool in the detection of active LN.|Animals[MESH]|Antigen-Antibody Complex/immunology[MESH]|Apoptosis/immunology[MESH]|Autoantibodies/*blood[MESH]|Biomarkers/blood[MESH]|Complement C1q/*immunology[MESH]|Complement Pathway, Classical[MESH]|Disease Progression[MESH]|Humans[MESH]|Immunity, Innate[MESH]|Lupus Erythematosus, Systemic/blood/*immunology[MESH]|Lupus Nephritis/diagnosis/immunology[MESH] |
