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Weight loss produced by tesofensine in patients with Parkinson s or Alzheimer s disease Astrup A; Meier DH; Mikkelsen BO; Villumsen JS; Larsen TMObesity (Silver Spring) 2008[Jun]; 16 (6): 1363-9OBJECTIVE: Tesofensine (TE) is a norepinephrine, dopamine, and serotonin reuptake inhibitor. We conducted a meta-analysis of TE's effect on body weight in trials investigating its potential for treatment of Parkinson's or Alzheimer's disease. METHODS AND PROCEDURES: Four randomized, double-blind, multicenter trials compared TE (n = 740) and placebo (n = 228), two in each disease. Patients received oral TE or placebo once daily for 14 weeks without any weight loss program. Results were adjusted for baseline values, age, and study. RESULTS: In the placebo group, 14% were obese and 21% were in the TE group. In the total cohort, weight change after 14 weeks was +0.5, -0.5, -0.9, -1.8, -2.8% in the placebo, 0.125, 0.25, 0.5 and 1.0 mg in the TE groups, respectively (P = 0.015 for dose effect). In the obese subgroup, weight changes were -0.2, -1.7, -1.6, -1.5, -3.7%, and 2.1, 8.2, 14.1, 20.9, 32.1% of the obese patients achieved > or = 5% weight loss (P < 0.001 for 0.25, 0.5, and 1.0 mg vs. placebo for both end points). Changes in heart rate were -0.4, 2.1, 4.2, 6.0, and 6.8 bpm after 14 weeks (TE vs. placebo: P < 0.001 from 0.25 mg), but no effect on blood pressure was observed. DISCUSSION: TE produced a placebo-subtracted weight loss of approximately 4% for >14 weeks without any diet and lifestyle therapy, which is similar to that of sibutramine, but with no effect on blood pressure. On the basis of these results, TE is now being developed for obesity management.|Adult[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Alzheimer Disease/drug therapy/*physiopathology[MESH]|Biogenic Monoamines/*antagonists & inhibitors[MESH]|Blood Pressure/drug effects/physiology[MESH]|Bridged Bicyclo Compounds, Heterocyclic/adverse effects/*pharmacology/therapeutic use[MESH]|Dose-Response Relationship, Drug[MESH]|Double-Blind Method[MESH]|Female[MESH]|Heart Rate/drug effects/physiology[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Multicenter Studies as Topic[MESH]|Obesity/drug therapy/physiopathology[MESH]|Parkinson Disease/drug therapy/*physiopathology[MESH]|Randomized Controlled Trials as Topic[MESH]|Selective Serotonin Reuptake Inhibitors/adverse effects/*pharmacology/therapeutic use[MESH]|Weight Loss/*drug effects/*physiology[MESH] |
