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Porous NiTi for bone implants: a review Bansiddhi A; Sargeant TD; Stupp SI; Dunand DCActa Biomater 2008[Jul]; 4 (4): 773-82NiTi foams are unique among biocompatible porous metals because of their high recovery strain (due to the shape-memory or superelastic effects) and their low stiffness facilitating integration with bone structures. To optimize NiTi foams for bone implant applications, two key areas are under active study: synthesis of foams with optimal architectures, microstructure and mechanical properties; and tailoring of biological interactions through modifications of pore surfaces. This article reviews recent research on NiTi foams for bone replacement, focusing on three specific topics: (i) surface modifications designed to create bio-inert porous NiTi surfaces with low Ni release and corrosion, as well as bioactive surfaces to enhance and accelerate biological activity; (ii) in vitro and in vivo biocompatibility studies to confirm the long-term safety of porous NiTi implants; and (iii) biological evaluations for specific applications, such as in intervertebral fusion devices and bone tissue scaffolds. Possible future directions for bio-performance and processing studies are discussed that could lead to optimized porous NiTi implants.|*Prostheses and Implants[MESH]|Alloys/*chemistry[MESH]|Animals[MESH]|Biocompatible Materials/chemistry[MESH]|Bone Substitutes/*chemistry[MESH]|Porosity[MESH]|Surface Properties[MESH] |
