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Tregs and rheumatoid arthritis Anderson AE; Isaacs JDActa Reumatol Port 2008[Jan]; 33 (1): 17-33Regulatory T cells (Tregs) are a subset of T cells which are involved in peripheral immune tolerance. Their role in autoimmune disease which occurs through a breakdown of tolerance is of particular interest in trying to ascertain the mechanism(s) of disease progression. It is hoped that by understanding the role of Tregs in autoimmunity a reliable therapy may be developed to aid in both the treatment and potentially cure of disease. This review will focus on the naturally-occurring CD4+ CD25+ regulatory T cell subset and their possible involvement in rheumatoid arthritis.|Animals[MESH]|Arthritis, Rheumatoid/drug therapy/*immunology[MESH]|CD4 Antigens[MESH]|Humans[MESH]|Interleukin-2 Receptor alpha Subunit[MESH]|T-Lymphocytes, Regulatory/*immunology[MESH]|Tumor Necrosis Factor-alpha/antagonists & inhibitors[MESH] |
