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  • Tregs and rheumatoid arthritis
  • Anderson AE; Isaacs JD
  • Acta Reumatol Port 2008[Jan]; 33 (1): 17-33
  • Regulatory T cells (Tregs) are a subset of T cells which are involved in peripheral immune tolerance. Their role in autoimmune disease which occurs through a breakdown of tolerance is of particular interest in trying to ascertain the mechanism(s) of disease progression. It is hoped that by understanding the role of Tregs in autoimmunity a reliable therapy may be developed to aid in both the treatment and potentially cure of disease. This review will focus on the naturally-occurring CD4+ CD25+ regulatory T cell subset and their possible involvement in rheumatoid arthritis.
  • |Animals[MESH]
  • |Arthritis, Rheumatoid/drug therapy/*immunology[MESH]
  • |CD4 Antigens[MESH]
  • |Humans[MESH]
  • |Interleukin-2 Receptor alpha Subunit[MESH]
  • |T-Lymphocytes, Regulatory/*immunology[MESH]
  • |Tumor Necrosis Factor-alpha/antagonists & inhibitors[MESH]

  • *{{pmid18344919}}
    *<b>[ Tregs and rheumatoid arthritis ]</b> Acta Reumatol Port 2008; 33(1) ; 17-33 Anderson AE; Isaacs JD


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    Acta Reumatol Port

    17 1.33 2008