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lüll The fidelity, occasional promiscuity, and versatility of T cell receptor recognition Godfrey DI; Rossjohn J; McCluskey JImmunity 2008[Mar]; 28 (3): 304-14Although there are multiple structures showing how alphabeta T cell receptors (TCRs) specifically recognize antigenic peptides bound to the major histocompatibility complex (MHC) molecules (pMHC-I and pMHC-II), we have little data on how TCRs interact with lipid-based antigens presented by members of the CD1 family. Here, we review recent findings in the field of TCR recognition, including TCR-pMHC complexes and the structure of a TCR in complex with CD1d-glycolipid. Collectively, these studies have revealed the versatility of the TCR in recognizing the distinct yet evolutionarily related proteinaceous and lipid-presenting molecules of the immune system.|Animals[MESH]|Antigen Presentation/*immunology[MESH]|Antigens, CD1/immunology[MESH]|Antigens, CD1d[MESH]|Glycolipids/immunology[MESH]|Humans[MESH]|Lymphocyte Activation/*immunology[MESH]|Major Histocompatibility Complex/immunology[MESH]|Receptors, Antigen, T-Cell/*immunology/metabolism[MESH]|T-Lymphocytes/*immunology/metabolism[MESH] |