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Diffusion tensor MR imaging and fiber tractography: theoretic underpinnings Mukherjee P; Berman JI; Chung SW; Hess CP; Henry RGAJNR Am J Neuroradiol 2008[Apr]; 29 (4): 632-41In this article, the underlying theory of clinical diffusion MR imaging, including diffusion tensor imaging (DTI) and fiber tractography, is reviewed. First, a brief explanation of the basic physics of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) mapping is provided. This is followed by an overview of the additional information that can be derived from the diffusion tensor, including diffusion anisotropy, color-encoded fiber orientation maps, and 3D fiber tractography. This article provides the requisite background for the second article in this 2-part review to appear next month, which covers the major technical factors that affect image quality in diffusion MR imaging, including the acquisition sequence, magnet field strength, gradient amplitude and slew rate, and multichannel radio-frequency coils and parallel imaging. The emphasis is on optimizing these factors for state-of-the-art DWI and DTI based on the best available evidence in the literature.|*Brain Mapping[MESH]|*Diffusion Magnetic Resonance Imaging[MESH]|Anisotropy[MESH]|Brain Diseases/*diagnosis[MESH]|Brain/*pathology[MESH]|Diffusion[MESH]|Humans[MESH]|Neural Pathways[MESH] |
