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lüll Wnt/beta-catenin signaling: new (and old) players and new insights Huang H; He XCurr Opin Cell Biol 2008[Apr]; 20 (2): 119-25Wnt/beta-catenin signaling has central roles in embryogenesis and human diseases including cancer. A central scheme of the Wnt pathway is to stabilize the transcription coactivator beta-catenin by preventing its phosphorylation-dependent degradation. Significant progress has been made toward the understanding of this crucial regulatory pathway, including the protein complex that promotes beta-catenin phosphorylation-degradation, and the mechanism by which the extracellular Wnt ligand engages cell surface receptors to inhibit beta-catenin phosphorylation-degradation. Here we review some recent discoveries in these two areas, and highlight some crucial questions that remain to be resolved.|*Signal Transduction[MESH]|Animals[MESH]|Axin Protein[MESH]|Humans[MESH]|Protein Processing, Post-Translational[MESH]|Repressor Proteins/metabolism[MESH]|Tumor Suppressor Proteins/metabolism[MESH]|Wnt Proteins/*metabolism[MESH]|beta Catenin/*metabolism[MESH] |