Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Fixing DNA breaks during class switch recombination Jolly CJ; Cook AJ; Manis JPJ Exp Med 2008[Mar]; 205 (3): 509-13Immunoglobulin (Ig) class switch recombination (CSR) involves the breakage and subsequent repair of two DNA sequences, known as switch (S) regions, which flank IgH constant region exons. The resolution of CSR-associated breaks is thought to require the nonhomologous end-joining (NHEJ) DNA repair pathway, but the role of the NHEJ factor DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in this process has been unclear. A new study, in which broken IgH-containing chromosomes in switching B cells were visualized directly, clearly demonstrated that DNA-PKcs and, unexpectedly, the nuclease Artemis are involved in the resolution of switch breaks.|*DNA Breaks[MESH]|*Immunoglobulin Class Switching[MESH]|Animals[MESH]|B-Lymphocytes/immunology/metabolism[MESH]|Chromosome Breakage[MESH]|DNA Repair/*genetics/*immunology[MESH]|DNA-Activated Protein Kinase/metabolism[MESH]|DNA-Binding Proteins/metabolism[MESH]|Humans[MESH]|Immunoglobulin Heavy Chains/genetics[MESH]|In Situ Hybridization, Fluorescence[MESH]|Mice[MESH]|Models, Genetic[MESH]|Models, Immunological[MESH]|Nuclear Proteins/metabolism[MESH]|Recombination, Genetic[MESH] |
