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lüll Scleroderma-like fibrosing disorders Boin F; Hummers LKRheum Dis Clin North Am 2008[Feb]; 34 (1): 199-220; ixMany conditions presenting with clinical hard skin and tissue fibrosis can be confused with systemic sclerosis (scleroderma). These disorders have very diverse etiologies and often an unclear pathogenetic mechanism. Distinct clinical characteristics, skin histology, and disease associations may allow one to distinguish these conditions from scleroderma and from each other. A prompt diagnosis is important to spare patients from ineffective treatments and inadequate management. This article highlights nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy), eosinophilic fasciitis (Shulman's syndrome), scleromyxedema, and scleredema. These often are detected in the primary care setting and referred to rheumatologists for further evaluation. Rheumatologists must be able to promptly recognize them to provide valuable prognostic information and appropriate treatment options for affected patients.|Diagnosis, Differential[MESH]|Fasciitis/diagnosis/pathology[MESH]|Fibrosis/*diagnosis/*etiology/pathology[MESH]|Humans[MESH]|Scleroderma, Diffuse/*diagnosis[MESH]|Scleromyxedema/diagnosis/pathology[MESH]|Skin/pathology[MESH] |