Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
CDC25A phosphatase: a rate-limiting oncogene that determines genomic stability Ray D; Kiyokawa HCancer Res 2008[Mar]; 68 (5): 1251-3CDC25A is a critical regulator of cell cycle progression and checkpoint response. Overexpression of this cyclin-dependent kinase phosphatase occurs often in human cancers. Our recent genetic studies in the mouse indicate that restricting CDC25A can limit tumorigenesis induced by the HER2/neu-RAS oncogenic pathway without compromising normal cell division or viability. These findings offer a sound foundation to justify development of CDC25A inhibitors for antitumor therapy.|*Gene Expression Regulation, Enzymologic[MESH]|*Gene Expression Regulation, Neoplastic[MESH]|Animals[MESH]|Cell Cycle[MESH]|Disease Progression[MESH]|Genome[MESH]|Genomic Instability[MESH]|Humans[MESH]|Mammary Neoplasms, Animal/genetics[MESH]|Mice[MESH]|Models, Biological[MESH]|Neoplasms/*genetics/*metabolism[MESH]|Receptor, ErbB-2/metabolism[MESH]|cdc25 Phosphatases/chemistry/*physiology[MESH]|ras Proteins/metabolism[MESH] |
