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lüll Apicomplexa in mammalian cells: trafficking to the parasitophorous vacuole Cesbron-Delauw MF; Gendrin C; Travier L; Ruffiot P; Mercier CTraffic 2008[May]; 9 (5): 657-64Most Apicomplexa reside and multiply in the cytoplasm of their host cell, within a parasitophorous vacuole (PV) originating from both parasite and host cell components. Trafficking of parasite-encoded proteins destined to membrane compartments beyond the confine of the parasite plasma membrane is a process that offers a rich territory to explore novel mechanisms of protein-membrane interactions. Here, we focus on the PVs formed by the asexual stages of two pathogens of medical importance, Plasmodium and Toxoplasma. We compare the PVs of both parasites, with a particular emphasis on their evolutionary divergent compartmentalization within the host cell. We also discuss the existence of peculiar export mechanisms and/or sorting determinants that are potentially involved in the post-secretory targeting of parasite proteins to the PV subcompartments.|Animals[MESH]|Apicomplexa/cytology/*metabolism/*pathogenicity[MESH]|Cell Membrane/metabolism[MESH]|Host-Parasite Interactions[MESH]|Plasmodium falciparum/metabolism/pathogenicity[MESH]|Toxoplasma/metabolism/pathogenicity[MESH]|Vacuoles/*metabolism[MESH] |