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lüll Ventricular-vascular interaction in heart failure Borlaug BA; Kass DAHeart Fail Clin 2008[Jan]; 4 (1): 23-36Nearly half of all patients who have heart failure have preserved ejection fraction (HFpEF). Patients who have HFpEF tend to be older, female, and hypertensive, and characteristically display increased ventricular and arterial stiffening. In this article, we discuss the pathophysiology of abnormal ventriculoarterial stiffening and how it affects ventricular function, cardiovascular hemodynamics, reserve capacity, and symptoms. We conclude by exploring how novel treatment strategies targeting abnormal ventricular-arterial interaction might prove useful in the treatment of patients who have HFpEF.|*Stroke Volume[MESH]|Age Factors[MESH]|Cardiac Output[MESH]|Diastole[MESH]|Endothelium[MESH]|Heart Failure/*physiopathology[MESH]|Heart Ventricles/*physiopathology[MESH]|Hemodynamics[MESH]|Humans[MESH]|Myocardial Contraction[MESH]|Systole[MESH]|Vascular Resistance[MESH] |