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lüll Regulation of cell structure and function by actin-binding proteins: villin s perspective Khurana S; George SPFEBS Lett 2008[Jun]; 582 (14): 2128-39Villin is a tissue-specific actin modifying protein that is associated with actin filaments in the microvilli and terminal web of epithelial cells. It belongs to a large family of actin-binding proteins which includes actin-capping, -nucleating and/or -severing proteins such as gelsolin, severin, fragmin, adseverin/scinderin and actin crosslinking proteins such as dematin and supervillin. Studies done in epithelial cell lines and villin knock-out mice have demonstrated the function of villin in regulating actin dynamics, cell morphology, epithelial-to-mesenchymal transition, cell migration and cell survival. In addition, the ligand-binding properties of villin (F-actin, G-actin, calcium, phospholipids and phospholipase C-gamma1) are mechanistically important for the crosstalk between signaling pathways and actin reorganization in epithelial cells.|Actins/*metabolism[MESH]|Animals[MESH]|Apoptosis[MESH]|Apoptosis Regulatory Proteins/*chemistry/genetics/*metabolism[MESH]|Cell Movement[MESH]|Cell Survival[MESH]|Epithelial Cells/cytology/metabolism/*physiology[MESH]|Humans[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Microfilament Proteins/*chemistry/genetics/*metabolism[MESH]|Protein Structure, Tertiary[MESH] |