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  • Targeting T regulatory cells in autoimmune diseases
  • Toubi E
  • Isr Med Assoc J 2008[Jan]; 10 (1): 73-6
  • Among the several mechanisms that play a role in maintaining peripheral self-tolerance is the existence of a unique CD4+CD25+ population of naturally occurring regulatory T cells, which actively prevent both the activation and the effector function of autoreactive T cells that have escaped different mechanisms of tolerance. Many studies have shown the benefit of targeting this cell population by restoring self-tolerance. Therapies that could possibly increase the suppressive ability of T regulatory cells were proven to improve the course of autoimmune diseases.
  • |Antibodies, Monoclonal, Murine-Derived[MESH]
  • |Antibodies, Monoclonal/pharmacology/therapeutic use[MESH]
  • |Autoimmune Diseases/*drug therapy/metabolism[MESH]
  • |Down-Regulation[MESH]
  • |Forkhead Transcription Factors/metabolism[MESH]
  • |Glucocorticoids/pharmacology/therapeutic use[MESH]
  • |Humans[MESH]
  • |Immunoglobulins, Intravenous/pharmacology/therapeutic use[MESH]
  • |Immunologic Factors/pharmacology/therapeutic use[MESH]
  • |Infliximab[MESH]
  • |Interleukin-10/metabolism[MESH]
  • |Lymphocyte Activation/drug effects[MESH]
  • |RNA, Messenger/metabolism[MESH]
  • |Rituximab[MESH]
  • |T-Lymphocytes, Regulatory/*drug effects[MESH]
  • |Tumor Necrosis Factor-alpha/pharmacology/therapeutic use[MESH]

  • *{{pmid18300580}}
    *<b>[ Targeting T regulatory cells in autoimmune diseases ]</b> Isr Med Assoc J 2008; 10(1) ; 73-6 Toubi E


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    Isr Med Assoc J

    73 1.10 2008