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Inflammation and cancer: role of nuclear factor-kappaB activation Maeda S; Omata MCancer Sci 2008[May]; 99 (5): 836-42It has been thought that there is a strong relationship between inflammation and carcinogenesis so that the development of cancer occurs with chronic inflammation in many organs. An in-depth understanding of the mechanism by which inflammation can lead to carcinogenesis may enable the development of drugs targeted at important molecules, providing a powerful tool for preventing cancer development. In this review, we focused on a signal transduction system, the nuclear factor-kappaB (NF-kappaB) pathway, which is thought to play a role in the process leading from inflammation to carcinogenesis, and may thus serve as a candidate for targeted intervention.|Animals[MESH]|Cell Transformation, Neoplastic[MESH]|Humans[MESH]|Inflammation/*metabolism[MESH]|Liver Neoplasms/metabolism[MESH]|Models, Biological[MESH]|NF-kappa B/*metabolism[MESH]|Neoplasms/immunology/*metabolism[MESH]|Signal Transduction[MESH]|Stomach Neoplasms/metabolism[MESH] |
