Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Calcium and phosphate homeostasis: concerted interplay of new regulators Renkema KY; Alexander RT; Bindels RJ; Hoenderop JGAnn Med 2008[]; 40 (2): 82-91Calcium (Ca(2+)) and phosphate (P(i)) are essential to many vital physiological processes. Consequently the maintenance of Ca(2+) and P(i) homeostasis is essential to a healthy existence. This occurs through the concerted action of intestinal, renal, and skeletal regulatory mechanisms. Ca(2+) and P(i) handling by these organs is under tight hormonal control. Disturbances in their homeostasis have been linked to pathophysiological disorders including chronic renal insufficiency, kidney stone formation, and bone abnormalities. Importantly, the kidneys fine-tune the amount of Ca(2+) and P(i) retained in the body by altering their (re)absorption from the glomerular filtrate. The ion transport proteins involved in this process have been studied extensively. Recently, new key players have been identified in the regulation of the Ca(2+) and P(i) balance. Novel regulatory mechanisms and their implications were introduced for the antiaging hormone klotho and fibroblast growth factor member 23 (FGF23). Importantly, transgenic mouse models, exhibiting disturbances in Ca(2+) and P(i) balance, have been of great value in the elucidation of klotho and FGF23 functioning. This review highlights the current knowledge and ongoing research into Ca(2+) and P(i) homeostasis, emphasizing findings from several relevant knockout mouse models.|*Homeostasis[MESH]|25-Hydroxyvitamin D3 1-alpha-Hydroxylase/metabolism[MESH]|Animals[MESH]|Calcitonin/metabolism[MESH]|Calcitriol/metabolism[MESH]|Calcium Channels/physiology[MESH]|Calcium Metabolism Disorders/metabolism[MESH]|Calcium/*metabolism[MESH]|Estrogens/metabolism[MESH]|Fibroblast Growth Factor-23[MESH]|Fibroblast Growth Factors/metabolism[MESH]|Glucuronidase/metabolism[MESH]|Humans[MESH]|Klotho Proteins[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Parathyroid Hormone/metabolism[MESH]|Phosphate Transport Proteins/physiology[MESH]|Phosphates/*metabolism[MESH]|Phosphorus Metabolism Disorders/metabolism[MESH]|Receptors, Calcium-Sensing/metabolism[MESH]|Renal Insufficiency, Chronic/physiopathology[MESH]|TRPV Cation Channels/physiology[MESH]|Tissue Kallikreins/metabolism[MESH] |
