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  • The invention and development of enflurane, isoflurane, sevoflurane, and desflurane
  • Terrell RC
  • Anesthesiology 2008[Mar]; 108 (3): 531-3
  • Thirty-six halogenated Me Et ethers have been synthesized for evaluation as volatile anesthetics. Eleven of the ethers were too unstable to test, and, of the remaining 25, 13 had promising anesthetic properties in mice and are suitable for study in larger animals. Those ethers having one H with at least 2 halogens other than F or 2 or more H with at least one Br or Cl were the best anesthetics.
  • |Animals[MESH]
  • |Chemistry, Pharmaceutical/methods/trends[MESH]
  • |Desflurane[MESH]
  • |Drug Design[MESH]
  • |Enflurane/*chemical synthesis[MESH]
  • |Humans[MESH]
  • |Hydrocarbons, Fluorinated/chemical synthesis[MESH]
  • |Isoflurane/*analogs & derivatives/*chemical synthesis[MESH]
  • |Methyl Ethers/*chemical synthesis[MESH]
  • |Sevoflurane[MESH]





  • *{{pmid18292690}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=18292690 The invention and development of enflurane, isoflurane, sevoflurane, and desflurane ]</b> Anesthesiology 2008; 108(3) ; 531-3 Terrell RC

        *18292690*

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    Anesthesiology

    531 3.108 2008