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Applications for ROCK kinase inhibition Olson MFCurr Opin Cell Biol 2008[Apr]; 20 (2): 242-8ROCK kinases, which play central roles in the organization of the actin cytoskeleton, are tantalizing targets for the treatment of human diseases. Deletion of ROCK I in mice revealed a role in the pathophysiological responses to high blood pressure, and validated ROCK inhibition for the treatment of specific types of cardiovascular disease. To date, the only ROCK inhibitor employed clinically in humans is fasudil, which has been used safely in Japan since 1995 for the treatment of cerebral vasospasm. Clinical trials, mostly focusing on the cardiovascular system, have uncovered beneficial effects of fasudil for additional indications. Intriguing recent findings also suggest significant potential for ROCK inhibitors in the production and implantation of stem cells for disease therapies.|Animals[MESH]|Apoptosis/drug effects[MESH]|Humans[MESH]|Protein Kinase Inhibitors/*pharmacology/therapeutic use[MESH]|Protein Structure, Tertiary[MESH]|Stem Cells/cytology/drug effects/enzymology[MESH]|rho-Associated Kinases/*antagonists & inhibitors/chemistry[MESH] |
