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Mechanisms of apoptosis resistance and treatment strategies to overcome them in hormone-refractory prostate cancer Uzzo RG; Haas NB; Crispen PL; Kolenko VMCancer 2008[Apr]; 112 (8): 1660-71New therapeutic strategies are needed to improve treatment outcomes in men with hormone-refractory prostate cancer. A better understanding of the molecular mechanisms of cell death in response to therapeutic strategies will help avoid ineffective treatment regimens and provide a molecular basis for new therapeutic modalities targeting apoptosis-resistant forms of prostate cancer. In this review, the authors focused on the established aberrations of apoptosis in hormone-refractory prostate cancer, and they have described novel treatment strategies to overcome apoptosis resistance.|Antineoplastic Agents, Hormonal/*therapeutic use[MESH]|Apoptosis Regulatory Proteins/physiology[MESH]|Apoptosis/drug effects/*physiology[MESH]|Cell Death/drug effects/physiology[MESH]|Drug Resistance, Neoplasm/drug effects/*physiology[MESH]|Humans[MESH]|Male[MESH]|Prostatic Neoplasms/*drug therapy[MESH]|Treatment Outcome[MESH] |
