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lüll Methoden zur Messung der Azetylsalizylsaure- bzw Clopidogrelresistenz Weber AA; Adamzik M; Bachmann HS; Gorlinger K; Grandoch M; Leineweber K; Muller-Beissenhirtz H; Wenzel F; Naber CHamostaseologie 2008[Feb]; 28 (1-2): 66-71Based on the concept that the so-called resistance to anti-platelet drugs is meant to describe a phenomenon where the drug does not hit its direct pharmacodynamic target, assays, used to evaluated the effects of anti-platelet drugs, should as closely as possible measure the direct pharmacodynamic effect of a particular drug. Thus, for the detection of aspirin effects, thromboxane concentrations or arachidonic acid-induced responses (light aggregometry, whole-blood aggregometry) should be measured. For the detection of clopidogrel actions, VASP phosphorylation (flow cytometry) or ADP-induced responses (light aggregometry, whole blood aggregometry) should be analysed.|*Drug Resistance[MESH]|Aspirin/*therapeutic use[MESH]|Clopidogrel[MESH]|Humans[MESH]|Platelet Aggregation Inhibitors/*therapeutic use[MESH]|Platelet Aggregation/*drug effects[MESH]|Ticlopidine/*analogs & derivatives/therapeutic use[MESH] |