Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Magnetic resonance imaging assessment of excess iron in thalassemia, sickle cell disease and other iron overload diseases Wood JC; Ghugre NHemoglobin 2008[]; 32 (1-2): 85-96Patients with transfusion-dependent anemia develop cardiac and endocrine toxicity from iron overload. Classically, serum ferritin and liver biopsy have been used to monitor patient response to chelation therapy. Recently, magnetic resonance imaging (MRI) has proven effective in detecting and quantifying iron in the heart and liver. Tissue iron is paramagnetic and increases the MRI relaxation rates R2 and R2* in a quantifiable manner. This review outlines the principles and validation of non invasive iron estimation by MRI, as well as discussing some of the technical considerations necessary for accurate measurements. Specifically, the use of R2 or R2* methods, choice of echo times, appropriate model for data fitting, the use of a pixel-wise or region-based measurement, and the choice of field strength are discussed.|Anemia, Sickle Cell/*diagnosis[MESH]|Chelation Therapy[MESH]|Ferritins/blood[MESH]|Humans[MESH]|Iron Overload/*diagnosis[MESH]|Iron/metabolism[MESH]|Liver/metabolism[MESH]|Magnetic Resonance Imaging/*methods[MESH]|Myocardium/metabolism[MESH]|Sensitivity and Specificity[MESH]|Thalassemia/*diagnosis[MESH] |
