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 Provisional hypotheses for the molecular genetics of cognitive development:  imaging genetic pathways in the anterior cingulate cortex Fossella J; Fan J; Liu X; Guise K; Brocki K; Hof PR; Kittappa R; McKay R; Posner MBiol Psychol  2008[Sep]; 79 (1): 23-9Brain imaging genetic research involves a multitude of methods and spans many  traditional levels of analysis. Given the vast permutations among several million  common genetic variants with thousands of brain tissue voxels and a wide array of  cognitive tasks that activate specific brain systems, we are prompted to develop  specific hypotheses that synthesize converging evidence and state clear  predictions about the anatomical sources, magnitude and direction (increases vs.  decreases) of allele- and task-specific brain activity associations. To begin to  develop a framework for shaping our imaging genetic hypotheses, we focus on  previous results and the wider imaging genetic literature. Particular emphasis is  placed on converging evidence that links system-level and biochemical studies  with models of synaptic function. In shaping our own imaging genetic hypotheses  on the development of Attention Networks, we review relevant literature on core  models of synaptic physiology and development in the anterior cingulate cortex.|Alleles[MESH]|Animals[MESH]|Cerebral Cortex/*anatomy & histology/growth & development/*physiology[MESH]|Cognition/*physiology[MESH]|Genotype[MESH]|Humans[MESH]|Magnetic Resonance Imaging[MESH]|Molecular Biology/*methods[MESH]|Oxygen/blood[MESH]
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