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lüll Phenotypic and functional heterogeneity of human memory B cells Sanz I; Wei C; Lee FE; Anolik JSemin Immunol 2008[Feb]; 20 (1): 67-82Memory B cells are more heterogeneous than previously thought. Given that B cells play powerful antibody-independent effector functions, it seems reasonable to assume division of labor between distinct memory B cells subpopulations in both protective and pathogenic immune responses. Here we review the information emerging regarding the heterogeneity of human memory B cells. A better understanding of this topic should greatly improve our ability to target specific B cell subsets either in vaccine responses or in autoimmune diseases and organ rejection among other pathological conditions where B cells play central pathogenic roles.|*Immunologic Memory[MESH]|ADP-ribosyl Cyclase 1/immunology[MESH]|Animals[MESH]|Antigens, CD19/immunology[MESH]|B-Lymphocyte Subsets/*cytology/*immunology[MESH]|Biomarkers[MESH]|Cell Lineage/immunology[MESH]|Humans[MESH]|Immunity, Cellular[MESH]|Immunoglobulin D[MESH]|Immunophenotyping[MESH]|Mice[MESH]|Tumor Necrosis Factor Receptor Superfamily, Member 7/immunology[MESH] |