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lüll BRCA1/2 associated hereditary breast cancer Teng LS; Zheng Y; Wang HHJ Zhejiang Univ Sci B 2008[Feb]; 9 (2): 85-9Breast cancer is one of the leading causes of death in women today. Some of the patients are hereditary, with a large proportion characterized by mutation in BRCA1 and/or BRCA2 genes. In this review, we provide an overview of these two genes, focusing on their relationship with hereditary breast cancers. BRCA1/2 associated hereditary breast cancers have unique features that differ from the general breast cancers, including alterations in cellular molecules, pathological bases, biological behavior, and a different prevention strategy. But the outcome of BRCA1/2 associated hereditary breast cancers still remains controversial; further studies are needed to elucidate the nature of BRCA1/2 associated hereditary breast cancers.|*Gene Expression Regulation, Neoplastic[MESH]|*Genetic Predisposition to Disease[MESH]|Apoptosis Regulatory Proteins[MESH]|BRCA1 Protein/*genetics/*physiology[MESH]|BRCA2 Protein/*genetics/*physiology[MESH]|Breast Neoplasms/*genetics/*metabolism[MESH]|Disease Progression[MESH]|Female[MESH]|Genetic Diseases, Inborn[MESH]|Humans[MESH]|Mutation[MESH]|Prognosis[MESH] |