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A common pathway for charge transport through voltage-sensing domains Chanda B; Bezanilla FNeuron 2008[Feb]; 57 (3): 345-51Voltage-gated ion channels derive their voltage sensitivity from the movement of specific charged residues in response to a change in transmembrane potential. Several studies on mechanisms of voltage sensing in ion channels support the idea that these gating charges move through a well-defined permeation pathway. This gating pathway in a voltage-gated ion channel can also be mutated to transport free cations, including protons. The recent discovery of proton channels with sequence homology to the voltage-sensing domains suggests that evolution has perhaps exploited the same gating pathway to generate a bona fide voltage-dependent proton transporter. Here we will discuss implications of these findings on the mechanisms underlying charge (and ion) transport by voltage-sensing domains.|*Ion Transport[MESH]|Animals[MESH]|Biological Transport/physiology[MESH]|Ion Channel Gating/*physiology[MESH]|Ion Channels/chemistry/*physiology[MESH]|Models, Biological[MESH]|Models, Molecular[MESH]|Protein Structure, Tertiary/*physiology[MESH] |
