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lüll Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors Lemos C; Jansen G; Peters GJBr J Cancer 2008[Mar]; 98 (5): 857-62Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected ABC-transporter family member, the breast cancer resistance protein (BCRP/ABCG2), in the (pre)clinical efficacy of novel experimental anticancer drugs, in particular tyrosine kinase inhibitors.|*Drug Resistance, Multiple[MESH]|*Drug Resistance, Neoplasm[MESH]|ATP Binding Cassette Transporter, Subfamily G, Member 2[MESH]|ATP-Binding Cassette Transporters/genetics/*physiology[MESH]|Animals[MESH]|Antineoplastic Agents/*pharmacology[MESH]|Biological Availability[MESH]|Hematopoietic Stem Cells/metabolism[MESH]|Humans[MESH]|Neoplasm Proteins/genetics/*physiology[MESH]|Protein Kinase Inhibitors/*pharmacology[MESH]|Protein-Tyrosine Kinases/*antagonists & inhibitors[MESH] |