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Neocentromeres: new insights into centromere structure, disease development, and karyotype evolution Marshall OJ; Chueh AC; Wong LH; Choo KHAm J Hum Genet 2008[Feb]; 82 (2): 261-82Since the discovery of the first human neocentromere in 1993, these spontaneous, ectopic centromeres have been shown to be an astonishing example of epigenetic change within the genome. Recent research has focused on the role of neocentromeres in evolution and speciation, as well as in disease development and the understanding of the organization and epigenetic maintenance of the centromere. Here, we review recent progress in these areas of research and the significant insights gained.|*Chromosome Aberrations[MESH]|*Evolution, Molecular[MESH]|Centromere/*genetics/physiology[MESH]|Epigenesis, Genetic/*genetics[MESH]|Genetic Speciation[MESH]|Humans[MESH]|Neoplasms/*genetics[MESH] |
