Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
Warning: file_get_contents(http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18246098&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 445
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Gates and filters: unveiling the physiological roles of nicotinic acetylcholine receptors in dopaminergic transmission Wonnacott SBr J Pharmacol 2008[Mar]; 153 Suppl 1 (Suppl 1): S2-4Neuronal nicotinic acetylcholine receptors (nAChRs) in the brain have been enigmatic players on the cerebral stage. As ligand-gated ion channels they were expected to mediate fast cholinergic transmission, yet their influence appears to be modulatory. Two reviews in this issue of the BJP consider the relationship between nAChRs and endogenous ACh, with respect to the modulation of dopaminergic signalling. In his review, Maskos posits that in midbrain dopamine neurons, somatodendritic nAChRs activated by cholinergic inputs from the pedunculopontine tegmental nucleus (PPTg) and laterodorsal tegmental nucleus (LDTg) serve as a 'gate' that facilitates the switch to burst firing. In the terminal field, Exley and Cragg argue that nAChRs function as a 'presynaptic filter' to enhance the contrast between single and repetitive spike firing. Thus somatodendritic and presynaptic nAChRs exert subtle and complementary influences in responding to cholinergic inputs.|Acetylcholine/physiology[MESH]|Animals[MESH]|Dopamine/*physiology[MESH]|Humans[MESH]|Receptors, Nicotinic/*physiology[MESH]|Signal Transduction[MESH]|Synaptic Transmission/*physiology[MESH] |
