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lüll STAT3 as a target for inducing apoptosis in solid and hematological tumors Al Zaid Siddiquee K; Turkson JCell Res 2008[Feb]; 18 (2): 254-67Studies in the past few years have provided compelling evidence for the critical role of aberrant Signal Transducer and Activator of Transcription 3 (STAT3) in malignant transformation and tumorigenesis. Thus, it is now generally accepted that STAT3 is one of the critical players in human cancer formation and represents a valid target for novel anticancer drug design. This review focuses on aberrant STAT3 and its role in promoting tumor cell survival and supporting the malignant phenotype. A brief evaluation of the current strategies targeting STAT3 for the development of novel anticancer agents against human tumors harboring constitutively active STAT3 will also be presented.|Animals[MESH]|Antineoplastic Agents/*therapeutic use[MESH]|Apoptosis/*drug effects[MESH]|Cell Survival/drug effects[MESH]|Cell Transformation, Neoplastic/drug effects/metabolism[MESH]|Drug Design[MESH]|Hematologic Neoplasms/*drug therapy/*metabolism[MESH]|Humans[MESH]|STAT3 Transcription Factor/*antagonists & inhibitors/*metabolism[MESH] |