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Tubulin modifications and their cellular functions Hammond JW; Cai D; Verhey KJCurr Opin Cell Biol 2008[Feb]; 20 (1): 71-6All microtubules are built from a basic alpha/beta-tubulin building block, yet subpopulations of microtubules can be differentially marked by a number of post-translational modifications. These modifications, conserved throughout evolution, are thought to act individually or in combination to control specific microtubule-based functions, analogous to how histone modifications regulate chromatin functions. Here we review recent studies demonstrating that tubulin modifications influence microtubule-associated proteins such as severing proteins, plus-end tracking proteins, and molecular motors. In this way, tubulin modifications play an important role in regulating microtubule properties, such as stability and structure, as well as microtubule-based functions, such as ciliary beating, cell division, and intracellular trafficking.|*Protein Processing, Post-Translational[MESH]|Acetylation[MESH]|Animals[MESH]|Dimerization[MESH]|Humans[MESH]|Microtubules/metabolism[MESH]|Protein Structure, Secondary[MESH]|Tubulin/*chemistry/*metabolism[MESH] |
