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lüll A microRNA component of the hypoxic response Kulshreshtha R; Davuluri RV; Calin GA; Ivan MCell Death Differ 2008[Apr]; 15 (4): 667-71microRNAs participate in a wide variety of physiological and pathological cellular processes. Recent studies have established a link between a specific group of microRNAs and hypoxia, a key feature of the neoplastic microenvironment. A significant proportion of the hypoxia-regulated microRNAs (HRMs) are also overexpressed in human cancers, suggesting a role in tumorigenesis. Preliminary evidence suggests that they could affect important processes such as apoptosis, proliferation and angiogenesis. Several HRMs exhibit induction in response to HIF activation, thus extending its repertoire of targets beyond translated genes. In the present review, we discuss the emerging roles of HRMs in oxygen deprivation in cancer context.|Animals[MESH]|Basic Helix-Loop-Helix Transcription Factors/*metabolism[MESH]|Cell Hypoxia[MESH]|Gene Expression Regulation, Neoplastic[MESH]|Humans[MESH]|Hypoxia-Inducible Factor 1/metabolism[MESH]|Hypoxia/genetics/*metabolism/pathology[MESH]|MicroRNAs/*metabolism[MESH]|Neoplasms/genetics/*metabolism/pathology[MESH]|Signal Transduction[MESH] |