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Hepatitis B virus escape mutants induced by antiviral therapy Sheldon J; Soriano VJ Antimicrob Chemother 2008[Apr]; 61 (4): 766-8The hepatitis B virus (HBV) polymerase and envelope genes overlap in such a way that resistance mutations to antiviral agents in the reverse transcriptase gene may affect the antigenicity of the HBV surface antigen. Mutant viruses may escape serological diagnosis using specific anti-HBV surface antigen antibodies, causing occult forms of chronic hepatitis B. Moreover, these HBV strains may evade vaccine protection, representing a public health challenge. Thus, the circulation of HBVs encoding envelope mutations selected by antiviral agents requires close monitoring.|*Mutation[MESH]|Antigens, Viral/genetics/*immunology[MESH]|Antiviral Agents/*therapeutic use[MESH]|Drug Resistance, Viral/*genetics[MESH]|Hepatitis B virus/drug effects/*genetics/*immunology[MESH]|Hepatitis B/drug therapy/*virology[MESH]|Humans[MESH] |
