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lüll Let me count the ways: mechanisms of gene regulation by miRNAs and siRNAs Wu L; Belasco JGMol Cell 2008[Jan]; 29 (1): 1-7The downregulation of gene expression by miRNAs and siRNAs is a complex process involving both translational repression and accelerated mRNA turnover, each of which appears to occur by multiple mechanisms. Moreover, under certain conditions, miRNAs are also capable of activating translation. A variety of cellular proteins have been implicated in these regulatory mechanisms, yet their exact roles remain largely unresolved.|Animals[MESH]|Caenorhabditis elegans/genetics[MESH]|Drosophila melanogaster/genetics[MESH]|Eukaryotic Initiation Factors/physiology[MESH]|Gene Expression Regulation/*genetics[MESH]|Humans[MESH]|MicroRNAs/*genetics[MESH]|Models, Genetic[MESH]|Protein Biosynthesis/genetics[MESH]|RNA Caps/genetics[MESH]|RNA Interference[MESH]|RNA Processing, Post-Transcriptional[MESH]|RNA Stability/genetics[MESH]|RNA, Helminth/genetics[MESH]|RNA, Messenger/genetics/metabolism[MESH]|RNA, Small Interfering/*genetics[MESH]|RNA-Induced Silencing Complex/genetics[MESH] |