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lüll Adenosine 5 -monophosphate-activated protein kinase regulation of fatty acid oxidation in skeletal muscle Osler ME; Zierath JREndocrinology 2008[Mar]; 149 (3): 935-41AMP-activated protein kinase (AMPK) is master regulator of energy balance through suppression of ATP-consuming anabolic pathways and enhancement of ATP-producing catabolic pathways. AMPK is activated by external metabolic stresses and subsequently orchestrates a complex downstream signaling cascade that mobilizes the cell for efficient energy production. AMPK has emerged as a key kinase driving lipid oxidation in skeletal muscle, and this function has important implications for exercise adaptations as well as metabolic defects associated with obesity.|AMP-Activated Protein Kinases[MESH]|Animals[MESH]|Exercise/physiology[MESH]|Fatty Acids/*metabolism[MESH]|Humans[MESH]|Lipid Metabolism/physiology[MESH]|Multienzyme Complexes/genetics/*metabolism[MESH]|Muscle, Skeletal/*metabolism[MESH]|Mutation[MESH]|Oxidation-Reduction[MESH]|Protein Serine-Threonine Kinases/genetics/*metabolism[MESH] |