Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Review of bosentan in the management of pulmonary arterial hypertension Gabbay E; Fraser J; McNeil KVasc Health Risk Manag 2007[]; 3 (6): 887-900The dual endothelin receptor antagonist, bosentan, is an orally active therapy, which is effective in the treatment of pulmonary arterial hypertension (PAH). This review critically appraises the evidence for the efficacy of bosentan in idiopathic and familial PAH, in PAH associated with connective tissue disease and in PAH which may develop in association with other conditions. Data from the pivotal placebo controlled studies and their open labeled extensions as well as long term survival and quality of life data is presented. Data is also presented on the potential benefit of bosentan in patients with inoperable chronic thromboembolic pulmonary hypertension. The safety and tolerability of bosentan as well as drug interactions are discussed. Dosage recommendations in adults and pediatrics are presented. An algorithm is provided to guide the reader in monitoring potential increases in alanine and aspartate transaminase levels that may occur with bosentan use and the dose adjustments that are recommended as a result of any increase in the levels of these enzymes are shown. Finally, the role of bosentan as part of combination therapy in PAH is examined.|Antihypertensive Agents/economics/*therapeutic use[MESH]|Bosentan[MESH]|Connective Tissue Diseases/drug therapy[MESH]|Dose-Response Relationship, Drug[MESH]|Drug Interactions[MESH]|Drug Therapy, Combination[MESH]|Endothelin-1/metabolism[MESH]|Humans[MESH]|Hypertension, Pulmonary/*drug therapy/epidemiology/genetics[MESH]|Pediatrics[MESH]|Quality of Life[MESH]|Sulfonamides/economics/*therapeutic use[MESH] |