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lüll IL-24 modulates IFN-gamma expression in patients with tuberculosis Wu B; Huang C; Kato-Maeda M; Hopewell PC; Daley CL; Krensky AM; Clayberger CImmunol Lett 2008[Apr]; 117 (1): 57-62IL-24 is a newly described member of the IL-10 family. We previously demonstrated that PBMC from TB patients exhibited low levels of IL-24 and IFN-gamma compared to subjects with latent tuberculosis infection (LTBI). In order to investigate the role of IL-24 in IFN-gamma expression in TB patients, we stimulated PBMC from individuals with LTBI or TB patients with the Mtb-specific antigen, early secretory antigenic target-6 (ESAT-6) and measured cytokine expression using quantitative real-time PCR (qPCR). Exogenous IL-24 increased IFN-gamma expression in PBMC obtained from TB patients while neutralization of IL-24 reduced IFN-gamma expression in PBMC from subjects with LTBI. Exogenous IL-24 enhanced IFN-gamma expression by increasing expression of IL-12 family cytokines, including IL-12alpha, IL-12beta, IL-23alpha and IL-27, and by reducing FOXP3 expression in PBMC from TB patients. This is the first demonstration that IL-24 may play an important role in IFN-gamma expression following infection with Mtb.|Forkhead Transcription Factors/metabolism[MESH]|Gene Expression/drug effects[MESH]|Humans[MESH]|Interferon-gamma/genetics/*metabolism[MESH]|Interleukins/biosynthesis/metabolism/*pharmacology[MESH]|Leukocytes, Mononuclear/drug effects/immunology[MESH]|RNA, Messenger/metabolism[MESH]|Tuberculosis, Pulmonary/*immunology[MESH]|Up-Regulation[MESH] |