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Genetic background and the dilemma of translating mouse studies to humans Rivera J; Tessarollo LImmunity 2008[Jan]; 28 (1): 1-4C57BL/6 genetically modified mouse models are the accepted gold standard in biological studies. However, an increasing failure of translating the findings to human (patho)physiology casts doubt on using a single strain to address many questions.|*Genetics[MESH]|Animals[MESH]|Biomedical Research/*methods[MESH]|Disease Models, Animal[MESH]|Humans[MESH]|Mice[MESH]|Mice, Inbred C57BL/*genetics[MESH] |
